APIs and Tablets are coated to prevent bitter taste, improve stability or
modify the release of a drug. Regardless of why they are applied, or whether the
process takes place in a coating pan or a fluidized bed granulator, these
functional coatings can be difficult to remove from equipment surfaces.
Our innovative chemistries make cleaning easier, and help minimize scrubbing.
In some cases, our formulated detergents are simply sprayed on, left to sit for
10-15 minutes, then sprayed off. Baths are a convenient Clean-Out-Of-Place (COP)
option. Soiled equipment is immersed and left to soak, and an operator easily
removes the remaining residue. We also create innovative chemistries for
Clean-in-Place (CIP) systems that come standard with much of today’s new
We have strong alliances with many of the leading manufacturers of process
equipment, which has resulted in an understanding of the soil deposition and the
cleaning mechanisms that come standard with the equipment. We leverage this
knowledge in the determination of the critical process parameters (T.A.C.T.)
needed to affect a clean surface when used in conjunction with one of our
Dober’s powerful and accurate Application Cleaning Methodology (ACM) studies
can help you effectively and efficiently clean your tanks to required
specifications. We’ve created an
ACM Submission Form to help you get started. Simply tell us about your soil
and process, and mail it to us with a small residue sample and your Material
Safety Data Sheet (MSDS).
Next, our chemists use the critical cleaning process parameters of time,
action, concentration and temperature, or T.A.C.T., to find an ideal solution.
They’ll either identify an existing cleaning agent from our comprehensive line
of cGMP Chematic® detergents, or create custom formulations and
cleaning recommendations—flexibility you won’t always find from our competitors.
Results are presented in an easy-to-understand report, as well as a WebEx
presentation during which our chemists provide you with the graphic evidence of
the cleaning improvements we have achieved. The chemists who performed your
testing will be available for consultation during and after their research to
assist you in implementing our recommendations.
Since laboratory simulations don’t always simulate field conditions, we
conduct testing using full-scale Clean-In-Place (CIP) and Clean-Out-Of-Place
(COP) equipment at our state-of-the-art Innovation and Technology Center. Or we
can visit your facilities for real-world trials conducted with the assistance of
Dober works closely with leading production and cleaning equipment
manufacturers, so you can be sure that our products are designed to work with
Finally, we understand the importance of validation and provide analytical
test methods to support our detergent implementation.
Dober Formulated Detergents ACM Study
Laboratory simulation ensures reproducible cleaning
Common industry coatings are no problem with Dober chemistry
The right chemistry improves cleaning time and saves money
Challenging coatings on large equipment is not a problem
Innovative cleaning technologies improve cleaning and reduce