APIs and Tablets are coated to prevent bitter
taste, improve stability or modify the release
of a drug. Regardless of why they are applied,
or whether the process takes place in a coating
pan or a fluidized bed granulator, these
functional coatings can be difficult to remove
from equipment surfaces.
Our innovative chemistries make cleaning
easier, and help minimize scrubbing. In some
cases, our formulated detergents are simply
sprayed on, left to sit for 10-15 minutes, then
sprayed off. Baths are a convenient
Clean-Out-Of-Place (COP) option. Soiled
equipment is immersed and left to soak, and an
operator easily removes the remaining residue.
We also create innovative chemistries for
Clean-in-Place (CIP) systems that come standard
with much of today’s new equipment.
We have strong alliances with many of the
leading manufacturers of process equipment,
which has resulted in an understanding of the
soil deposition and the cleaning mechanisms that
come standard with the equipment. We leverage
this knowledge in the determination of the
critical process parameters (T.A.C.T.) needed to
affect a clean surface when used in conjunction
with one of our formulated detergents.
Dober’s powerful and accurate Application
Cleaning Methodology (ACM) studies can help you
effectively and efficiently clean your tanks to
required specifications. We’ve created an
ACM Submission Form to help you get started.
Simply tell us about your soil and process, and
mail it to us with a small residue sample and
your Material Safety Data Sheet (MSDS).
Next, our chemists use the critical cleaning
process parameters of time, action,
concentration and temperature, or T.A.C.T., to
find an ideal solution. They’ll either identify
an existing cleaning agent from our
comprehensive line of cGMP Chematic®
detergents, or create custom formulations and
cleaning recommendations—flexibility you won’t
always find from our competitors.
Results are presented in an
easy-to-understand report, as well as a WebEx
presentation during which our chemists provide
you with the graphic evidence of the cleaning
improvements we have achieved. The chemists who
performed your testing will be available for
consultation during and after their research to
assist you in implementing our recommendations.
Since laboratory simulations don’t always
simulate field conditions, we conduct testing
using full-scale Clean-In-Place (CIP) and
Clean-Out-Of-Place (COP) equipment at our
state-of-the-art Innovation and Technology
Center. Or we can visit your facilities for
real-world trials conducted with the assistance
of our team.
Dober works closely with leading production
and cleaning equipment manufacturers, so you can
be sure that our products are designed to work
with your equipment.
Finally, we offer a wide range of validation
services, and we’ll support you every step of
the way. For example, we can help you with
creating, auditing, reviewing and/or updating
cleaning validation policies, master plans,
standard operating procedures, product and
equipment grouping strategies, limits,
strategies for setting effective limits,
customized training and more.
Using our Validation Acceleration Strategy
(VAS), we’ll ensure that you have all necessary
information and documentation.
Dober Formulated Detergents ACM Study
Laboratory simulation ensures
reproducible cleaning recommendations
Common industry coatings are no problem
with Dober chemistry
The right chemistry improves cleaning
time and saves money
Challenging coatings on large equipment
is not a problem
Innovative cleaning technologies improve
cleaning and reduce labor